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Drug Information: Avapro

AVAPRO (Irbesartan), an Angiotensin II receptor antagonist is prescribed by the physicians for the treatment of hypertension in patients with or with out Type 2 Diabetes. AVAPRO (Irbesartan) inhibits the synthesis of Angiotensin II and prevents the vasoconstriction and improves the blood flow dynamics. AVAPRO (Irbesartan) can delay the progression of Diabetic nephropathy in Type 2 diabetic patients with significant Proteinuria and Beta -2 microglobinuria. AVAPRO (Irbesartan) can be given as a monotherapy or in combination with other anti-hypertensive drugs for the treatment of hypertension. AVAPRO (Irbesartan) is also prescribed for the patients with the depleted vascular volume and low body salt levels due to the treatment of diuretics or by the haemodialysis.

Who should not take AVAPRO (Irbesartan)?

AVAPRO (Irbesartan) should not be prescribed for the patients with history of liver and kidney diseases, systemic hypovolemia or in case of dehydration. You should not use AVAPRO (Irbesartan), if you are taking diuretics or the water pills like the amiloride, Spironolactone and triamterene, potassium salts, digoxin, Aspirin, ibuprofen, naproxen, anti-histamines, lithium, non-prescription drugs including herbal and nutrient supplements and anticoagulants like the coumarin. AVAPRO (Irbesartan) is classified as a Pregnancy category – D drug by the Food and Drug Administration (FDA) and it should not be used in pregnancy. If you are allergic to AVAPRO (Irbesartan), you should consult your physician before taking it. You should not use AVAPRO (Irbesartan), if you are nursing mother. AVAPRO (Irbesartan) is contraindicated in children less than 2 years.

AVAPRO (Irbesartan) Side Effects:

AVAPRO (Irbesartan) can cause side effects like diarrhoea, abdominal pain and heart burn, fever, edema, constipation, abdominal distension, pruritis, dermatitis, skin rashes, cardiac murmur, heart failure, angina pectoris, gout like symptoms, loss of libido, tinnitus, epistaxis, abnormal micturition, dyspnoea, sleeping disorders, mood swings, depression, angioedema and prostatic disorder. Rarely, AVAPRO (Irbesartan) can cause skeletal muscle breakdown (rhabdomyolysis) that may lead to the kidney failure.

How should I take AVAPRO (Irbesartan)?

The recommended oral dosage for the AVAPRO (Irbesartan) is 150 mg daily. In case of uncontrolled hypertension you may need 300 mg. For the treatment of diabetic nephropathy the recommended dose of AVAPRO (Irbesartan) is 300mg daily. For the treatment of depleted salt or volume, the recommended daily dosage of AVAPRO (Irbesartan) is 75mg. The following instruction should be followed to take the AVAPRO (Irbesartan) – 150 mg oral dosage daily: (1) You can take AVAPRO (Irbesartan) any time disregard of food intake 2) Take AVAPRO (Irbesartan) while you are sitting or standing up. 3) Take AVAPRO (Irbesartan) with 6 to 8 ounces (about 1 cup) of plain water. Do not take AVAPRO (Irbesartan) with any other drink besides plain water. Do not take AVAPRO (Irbesartan) with coffee, tea, juice, milk or other dairy drinks. 4) Swallow AVAPRO (Irbesartan) as a whole. Do not chew the tablet or keep AVAPRO (Irbesartan) in your mouth to melt or dissolve. After taking AVAPRO (Irbesartan) you must wait at least 30 minutes BEFORE: 1) lying down. You may sit, stand, or do normal activities like read the newspaper or take a walk. 2) Eating or drinking anything except plain water. Keep taking AVAPRO (Irbesartan) for as long as your health care provider tells you to do so. To treat your problems or keep you from getting these symptoms, you have to take AVAPRO (Irbesartan) as often and in the way AVAPRO (Irbesartan) as prescribed by your Physician.

What is the important information I should know about AVAPRO (Irbesartan)?

  • Take AVAPRO (Irbesartan) exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • You can take AVAPRO (Irbesartan) disregard of food intake.
  • For AVAPRO (Irbesartan) dosage one must follow his doctor's instructions.
  • It is important to take AVAPRO (Irbesartan) regularly to get the most benefit, as directed by the Physician.
  • You must avoid self medication including the over-the-counter drugs and also the nutritional supplements.
  • Check your blood pressure often while taking AVAPRO (Irbesartan).
  • Do not stop taking AVAPRO (Irbesartan) without first talking to your doctor, even if you are feeling well. Even after your symptoms improve, you may require continuous treatment for quite some time, as directed by the Physician.
  • Avoid consuming alcohol while you are using AVAPRO (Irbesartan).
  • Call your Physician if you experience abnormal symptoms like dark colour urine, fever and nausea.
  • Store AVAPRO (Irbesartan) as per the instructions on the label.
  • Keep AVAPRO (Irbesartan) away from the reach of the children and pets.

    What happens if I miss a dose of AVAPRO (Irbesartan)?

    Take the missed dose of AVAPRO (Irbesartan) as soon as you remember, during the same day. If you do not remember until the next day, skip the missed dose and take AVAPRO (Irbesartan) next day as routine dose. Do not take a double dose of the medication that may lead to serious side effects.

    What happens if I overdose of AVAPRO (Irbesartan)?

    In case of overdose, please seek emergency medical attention immediately.

    Where can I get more information on AVAPRO (Irbesartan)?

    AVAPRO (Irbesartan) prescribed patients, who try to place an order for AVAPRO (Irbesartan) from an online pharmacy store, can place their prescription order at the CanadaDrugsOnline.com which is an online Canadian pharmacy store.
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