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Drug Information: Sintrom

SINTROM (Acenocoumarol), an anti-coagulant drug is prescribed by the physicians for the treatment and the prevention of the clotting disorders like thromboembolism diseases. SINTROM (Acenocoumarol) is a vitamin K antagonist that inhibits vitamin K and also the vitamin K dependent coagulation proteins like the Factor II, VII, IX and X. This can greatly decrease the pro-thrombin levels and also the thrombin and fibrin clots, an end product of blood clot. SINTROM (Acenocoumarol) is not useful to dissolve already formed blood clots. SINTROM (Acenocoumarol) is also called as blood thinners.

Who should not take SINTROM (Acenocoumarol)?

SINTROM (Acenocoumarol) should not be prescribed for the patients with bleeding disorders, bruising, heart infections, diverticulitis, stomach cancer, aneurysm, brain haemorrhage, recent maternal delivery, leukaemia, haemophilia, type 2 diabetes, thrombocytopenia, liver secretory disorders, vitamin K deficiency, pregnancy complications including toxaemia and duodenal or gastric ulcers or perforations. If you are taking drugs like corticosteroids including anabolic steroids, thyroid medications, statins, Zileuton, NSAIDs, quinidine, Valproic acid, plicamycin, Griseofulvin, rifampicin, disulfiram, carbamazepine, Omeprazole, vitamin K and barbiturates, you should not take SINTROM (Acenocoumarol). SINTROM (Acenocoumarol) is contraindicated in pregnancy and breast feeding. SINTROM (Acenocoumarol) can cause birth defects and/or severe to fatal bleeding to the foetus if used in the second trimester of the pregnancy. SINTROM (Acenocoumarol) can pass through the breast milk and it can harm the feeding infant. SINTROM (Acenocoumarol) should not be given to elderly patients and also for the children below 2 years of age.

SINTROM (Acenocoumarol) Side Effects:

SINTROM (Acenocoumarol) can cause side effects like gastrointestinal bleeding, diarrhoea, headache, hematuria, malena (blood in the stools), vision changes, dyspnoea, abdominal distension, severe and prolonged headache or migraine like symptoms, bruising and easy and continuous bleeding even after minor cuts. Rarely, SINTROM (Acenocoumarol) can cause jaundice like symptoms, pruritis, fever with chills, allergic reactions, changes in the urinary output and painful sores in genital parts and in the buttocks.

How should I take SINTROM (Acenocoumarol)?

The recommended oral dosage of SINTROM (Acenocoumarol) is 0.4 mg daily and the dosage can be titrated from 1 to 10 mg daily according to the requirement of the patient. The instruction should be followed to take the SINTROM (Acenocoumarol) – 0.4 mg oral dosage daily: (1) Take SINTROM (Acenocoumarol) at least one and half hours after the food intake 2) Take SINTROM (Acenocoumarol) while you are sitting or standing up. 3) Take SINTROM (Acenocoumarol) with 6 to 8 ounces (about 1 cup) of plain water. Do not take SINTROM (Acenocoumarol) with any other drink besides plain water. Do not take SINTROM (Acenocoumarol) with coffee, tea, juice, milk or other dairy drinks. 4) Swallow SINTROM (Acenocoumarol) as a whole. Do not chew the tablet or keep SINTROM (Acenocoumarol) in your mouth to melt or dissolve. After taking SINTROM (Acenocoumarol) you must wait at least 30 minutes BEFORE: 1) lying down. You may sit, stand, or do normal activities like read the newspaper or take a walk. 2) Eating or drinking anything except plain water. Keep taking SINTROM (Acenocoumarol) for as long as your health care provider tells you to do so. To treat your problems or keep you from getting these symptoms, you have to take SINTROM (Acenocoumarol) as often and in the way SINTROM (Acenocoumarol) as prescribed by your Physician.

What is the important information I should know about SINTROM (Acenocoumarol)?

  • Take SINTROM (Acenocoumarol) exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • You should take SINTROM (Acenocoumarol) one and half hours after the meals.
  • For SINTROM (Acenocoumarol) dosage one must follow his doctor's instructions.
  • It is important to take SINTROM (Acenocoumarol) regularly to get the most benefit, as directed by the Physician.
  • Do not stop taking SINTROM (Acenocoumarol) without first talking to your doctor, even if you are feeling well. Even after your symptoms improve, you may require continuous treatment for quite some time, as directed by the Physician.
  • Avoid hot weather, playing sports and unintentional self injuries during shaving and brushing the teeth.
  • Do not take over-the-counter pain medications like the ibuprofen, mefenamic acid and even the vitamin supplements like Vitamin – K. These drugs can potentiate the effects of SINTROM (Acenocoumarol) that may lead to bleeding disorders.
  • Store SINTROM (Acenocoumarol) as per the instructions on the label.
  • Keep SINTROM (Acenocoumarol) away from the reach of the children and pets.

    What happens if I miss a dose of SINTROM (Acenocoumarol)?

    Take the missed dose of SINTROM (Acenocoumarol) as soon as you remember, during the same day. If you do not remember until the next day, skip the missed dose and take SINTROM (Acenocoumarol) next day as routine dose. Do not take a double dose of the medication that may lead to serious or even life threatening bleeding medical conditions.

    What happens if I overdose of SINTROM (Acenocoumarol)?

    In case of SINTROM (Acenocoumarol) overdose, please seek emergency medical attention immediately.

    Where can I get more information on SINTROM (Acenocoumarol)?

    SINTROM (Acenocoumarol) prescribed patients, who try to place an order for SINTROM (Acenocoumarol) from an online pharmacy store, can place their prescription order at the CanadaDrugsOnline.com which is an online Canadian pharmacy store.
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